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Target
Histone deacetylase 4 [648-1032]
Ligand
BDBM243176
Substrate
n/a
Meas. Tech.
HDAC4 Biochemical Assay
IC50
30.0±n/a nM
Citation
 Maillard, MC; Breccia, P; Dominguez, C; Haughan, AF; Van de Poël, A; Stott, AJ; Luckhurst, CA; Saville-Stones, EA; Wishart, G; Wall, M; Jarvis, RE Histone deacetylase inhibitors and compositions and methods of use thereof US Patent  US10053434 Publication Date 8/21/2018 
Target
Name:
Histone deacetylase 4 [648-1032]
Synonyms:
HDAC4 | HDAC4_HUMAN | Histone deacetylase 4 | KIAA0288
Type:
Enzyme
Mol. Mass.:
41490.90
Organism:
Homo sapiens (Human)
Description:
P56524[648-1032]
Residue:
385
Sequence:
TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQ
  
Inhibitor
Name:
BDBM243176
Synonyms:
(R)-N-(1-(6-Azaspiro[2.5]octan-6- yl)propan-2-yl)-4-(5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl)benzamide | US10053434, 12
Type:
Small organic molecule
Emp. Form.:
C20H23F3N4O2
Mol. Mass.:
408.4174
SMILES:
C[C@H](CN1CCC2(CC2)CC1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Structure:
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