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Target
Histone deacetylase 4 [648-1032]
Ligand
BDBM243203
Substrate
n/a
Meas. Tech.
HDAC4 Biochemical Assay
IC50
134±n/a nM
Citation
 Maillard, MC; Breccia, P; Dominguez, C; Haughan, AF; Van de Poël, A; Stott, AJ; Luckhurst, CA; Saville-Stones, EA; Wishart, G; Wall, M; Jarvis, RE Histone deacetylase inhibitors and compositions and methods of use thereof US Patent  US10053434 Publication Date 8/21/2018 
Target
Name:
Histone deacetylase 4 [648-1032]
Synonyms:
HDAC4 | HDAC4_HUMAN | Histone deacetylase 4 | KIAA0288
Type:
Enzyme
Mol. Mass.:
41490.90
Organism:
Homo sapiens (Human)
Description:
P56524[648-1032]
Residue:
385
Sequence:
TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQ
  
Inhibitor
Name:
BDBM243203
Synonyms:
N-((R)-1-((S)-2-Methylpyrrolidin-1- yl)propan-2-yl)-5-(5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl)picolinamide | US10053434, 24
Type:
Small organic molecule
Emp. Form.:
C17H20F3N5O2
Mol. Mass.:
383.3682
SMILES:
C[C@H](CN1CCC[C@@H]1C)NC(=O)c1ccc(cn1)-c1noc(n1)C(F)(F)F |r|
Structure:
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