Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMitogen-activated protein kinase 1
LigandBDBM243222
Substrate/Competitorn/a
Meas. Tech.Activated ERK2 Kinase Assay
pH7.5±n/a
IC50 21.0±n/a nM
Commentsextracted
Citation Dillon, MPLindvall, MPoon, DRamurthy, SRauniyar, VShafer, CSubramanian, STanner, HR Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors US Patent US9546173 Publication Date 1/17/2017
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (human)
Description:Obtained from Calbiochem.
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM243222
NameBDBM243222
Synonyms:US9546173, cmpd 19 | n-(3,5-difluorobenzyl)-5,5-dimethyl-2-((tetrahydro-2h-pyran-4-yl)amino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide
TypeSmall organic molecule
Emp. Form.C21H25F2N5O2
Mol. Mass.417.4523
SMILESCC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)NCc1cc(F)cc(F)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a