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Target
Tyrosine-protein kinase SYK
Ligand
BDBM243360
Substrate
n/a
Meas. Tech.
In Vitro SYK Inhibition Assay
pH
7.8±n/a
Temperature
298.15±n/a K
IC50
<500±n/a nM
Comments
extracted
Citation
 Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent  US10053455 Publication Date 8/21/2018 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM243360
Synonyms:
5-{5-[3-(4- Trifluoromethyl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-5,8- diaza-spiro[3.5]nonan-9- one | US10053455, 016
Type:
Small organic molecule
Emp. Form.:
C21H19F3N6O2
Mol. Mass.:
444.4098
SMILES:
FC(F)(F)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CCC2)n1
Structure:
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