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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM362662
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent  US9834565 Publication Date 12/5/2017 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM362662
Synonyms:
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}- N,2-dimethylpropanamide | US10227359, Example 17 | US9834565, Example 17
Type:
Small organic molecule
Emp. Form.:
C29H34N6O3
Mol. Mass.:
514.6187
SMILES:
CC(C)C(=O)N(C)C1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23 |(-3.56,8.21,;-4.33,6.88,;-5.87,6.88,;-3.56,5.55,;-4.33,4.21,;-2.02,5.55,;-1.25,6.88,;-1.25,4.21,;-2.02,2.88,;-1.25,1.54,;.29,1.54,;1.06,2.88,;.29,4.21,;1.06,.21,;2.6,.21,;3.16,-1.22,;4.49,-1.99,;4.49,-3.53,;3.16,-4.3,;3.16,-5.84,;1.91,-6.75,;.45,-6.27,;2.39,-8.21,;3.93,-8.21,;4.41,-6.75,;5.87,-6.27,;1.83,-3.53,;.49,-4.3,;-.84,-3.53,;-.84,-1.99,;-2.17,-1.22,;-3.51,-1.99,;-4.84,-1.22,;-4.84,.32,;-3.51,1.09,;-2.17,.32,;.49,-1.22,;1.83,-1.99,)|
Structure:
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