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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM362672
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent  US9834565 Publication Date 12/5/2017 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM362672
Synonyms:
(4S)-2-[4-(cyclopropylcarbonyl)piperazin- 1-yl]-7-(3,5-dimethylisoxazol-4-yl)-4- pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazine | US10227359, Example 27 | US10618910, Example 26 | US9834565, Example 27
Type:
Small organic molecule
Emp. Form.:
C27H28N6O3
Mol. Mass.:
484.5496
SMILES:
Cc1noc(C)c1-c1ccc2nc(N3CCN(CC3)C(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1 |wD:25.35,(-.04,-5.61,;1.43,-6.08,;1.9,-7.55,;3.44,-7.55,;3.92,-6.08,;5.39,-5.61,;2.67,-5.18,;2.67,-3.64,;4.01,-2.87,;4.01,-1.33,;2.67,-.56,;2.11,.88,;.57,.88,;-.2,2.21,;-1.74,2.21,;-2.51,3.55,;-1.74,4.88,;-.2,4.88,;.57,3.55,;-2.51,6.21,;-1.74,7.55,;-4.05,6.21,;-5.39,5.44,;-5.39,6.98,;.01,-.56,;-1.33,-1.33,;-1.33,-2.87,;.01,-3.64,;1.34,-2.87,;1.34,-1.33,;-2.66,-.56,;-3.99,-1.33,;-5.33,-.56,;-5.33,.98,;-3.99,1.75,;-2.66,.98,)|
Structure:
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