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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM362834
Substrate
n/a
Meas. Tech.
TAM Enzymatic Assay
IC50
550±n/a nM
Citation
 Sun, Y; Li, Y; Burns, DM Heterocyclic compounds and uses thereof US Patent  US9840503 Publication Date 12/12/2017 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM362834
Synonyms:
3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-(1-methyl-1H-pyrazol-4-yl)pyrimido[4,5-c]isoquinolin-6(5H)-one | US9840503, Example 7
Type:
Small organic molecule
Emp. Form.:
C25H30N6O2
Mol. Mass.:
446.5447
SMILES:
CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1cnn(C)c1 |r,wU:18.18,wD:21.22,(-8.52,-4.37,;-7.19,-3.6,;-5.85,-4.37,;-4.52,-3.6,;-3.19,-4.37,;-1.85,-3.6,;-.52,-4.37,;.82,-3.6,;.82,-2.06,;2.15,-1.29,;3.48,-2.06,;4.82,-1.29,;4.82,.25,;3.48,1.02,;2.15,.25,;.82,1.02,;.82,2.56,;-.52,.25,;-1.85,1.02,;-3.19,.25,;-4.52,1.02,;-4.52,2.56,;-5.85,3.33,;-3.19,3.33,;-1.85,2.56,;-.52,-1.29,;-1.85,-2.06,;6.15,1.02,;7.61,.54,;8.52,1.79,;7.61,3.04,;8.38,4.37,;6.15,2.56,)|
Structure:
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