Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM19736
Substrate
BDBM19485
Meas. Tech.
Enzyme Inhibition Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
<0.003±n/a nM
Km
35000±n/a nM
Citation
 Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Irie, O; Teno, N; Lattmann, R; Tintelnot-Blomley, M; Missbach, M 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem 50:591-4 (2007) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM19736
Synonyms:
2-Cyano-pyrimidine, 17a | 2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(4-methoxyphenyl)ethyl]pyrimidine-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C20H25N5O2
Mol. Mass.:
367.4448
SMILES:
COc1ccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19485
Synonyms:
Cbz-Phe-Arg-AMC | Fluorogenic substrate | Z-Phe-Arg-AMC.HCl
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: