Target
Cathepsin S
Ligand
BDBM19753
Substrate
BDBM19963
Meas. Tech.
Enzyme Inhibition Assay
IC50
2300±n/a nM
Citation
 Altmann, EAichholz, RBetschart, CBuhl, TGreen, JLattmann, RMissbach, M Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett 16:2549-54 (2006) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM19753
Synonyms:
benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(3-methylphenyl)ethyl]carbamoyl}-3-methylbutyl]carbamate | dipeptidyl nitrile, 5b
Type:
Small organic molecule
Emp. Form.:
C24H29N3O3
Mol. Mass.:
407.5054
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cccc(C)c1)C#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19963
Synonyms:
Cbz-Leu-Leu-Arg-AMC | Fluorogenic substrate | Z-Leu-Leu-Arg-AMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: