Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM19756
Substrate
BDBM19963
Meas. Tech.
Enzyme Inhibition Assay
IC50
>10000±n/a nM
Citation
 Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Lattmann, R; Missbach, M Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett 16:2549-54 (2006) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM19756
Synonyms:
benzyl N-[(1S)-1-{[(1S)-2-[4-(benzyloxy)phenyl]-1-cyanoethyl]carbamoyl}-3-methylbutyl]carbamate | dipeptidyl nitrile, 5e
Type:
Small organic molecule
Emp. Form.:
C30H33N3O4
Mol. Mass.:
499.6007
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19963
Synonyms:
Cbz-Leu-Leu-Arg-AMC | Fluorogenic substrate | Z-Leu-Leu-Arg-AMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: