Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM19791
Substrate
BDBM19490
Meas. Tech.
Enzyme Inhibition Assay
IC50
11±n/a nM
Citation
Barrett, DG; Catalano, JG; Deaton, DN; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Samano, V; Tavares, FX; Wells-Knecht, KJ; Wright, LL; Zhou, HQ Acyclic, orally bioavailable ketone-based cathepsin K inhibitors. Bioorg Med Chem Lett 17:22-7 (2007) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM19791
Synonyms:
(2S)-3,3-dimethyl-1-[3-(pyridin-4-yl)-1H-pyrazol-1-yl]butan-2-yl N-[(3S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-yl]carbamate | ketone analog, 3h
Type:
Small organic molecule
Emp. Form.:
C27H36N6O5S
Mol. Mass.:
556.677
SMILES:
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(n1)-c1ccncc1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 |r|