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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM143757
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
25.0±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US9845333 Publication Date 12/19/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM143757
Synonyms:
US10183953, Example 46 | US8969352, 18 | US8969352, 46 | US9611277, Example 46 | US9845333, 46
Type:
Small organic molecule
Emp. Form.:
C21H17F4N5O2
Mol. Mass.:
447.3856
SMILES:
Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 |TLB:14:13:9.10:26,7:9:13.12:26|
Structure:
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