Target
Orexin receptor type 2
Ligand
BDBM143780
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Ki
>10000±n/a nM
Citation
 Gelin, CFLebold, TPShireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US9845333 Publication Date 12/19/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R
Type:
Protein
Mol. Mass.:
52508.46
Organism:
Rattus norvegicus (Rat)
Description:
P56719
Residue:
460
Sequence:
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
  
Inhibitor
Name:
BDBM143780
Synonyms:
US10183953, Example 41 | US8969352, 41 | US9611277, Example 41 | US9845333, 41
Type:
Small organic molecule
Emp. Form.:
C24H23F3N4O2
Mol. Mass.:
456.4602
SMILES:
Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32,(.61,-1.24,;1.38,-2.58,;.9,-4.04,;2.15,-4.95,;3.4,-4.04,;4.73,-4.81,;2.92,-2.58,;4.01,-1.49,;5.5,-1.89,;6.59,-.8,;6.19,.69,;4.7,1.09,;3.61,-0,;2.12,.4,;1.03,-.69,;1.72,1.88,;2.5,3.22,;1.01,3.62,;-.48,3.22,;-1.25,1.88,;-1.25,.34,;-2.58,-.43,;-2.58,-1.97,;-3.92,-2.74,;-5.35,-1.98,;-5.25,-.43,;-3.92,.34,;-6.69,-2.74,;-8.03,-3.49,;-7.44,-1.4,;-5.93,-4.08,;.24,2.28,;.24,4.95,)|
Structure:
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