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Target
Rho-associated protein kinase 2 [11-552]
Ligand
BDBM362925
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1100±n/a nM
Citation
 Glick, GD 1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties US Patent  US9849138 Publication Date 12/26/2017 
Target
Name:
Rho-associated protein kinase 2 [11-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2
Type:
Protein
Mol. Mass.:
62268.16
Organism:
Homo sapiens (Human)
Description:
Chemicon #14-451
Residue:
542
Sequence:
PGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM362925
Synonyms:
US9849138, 1
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O2
Mol. Mass.:
391.85
SMILES:
CN1c2ccc(Cl)cc2C(=O)NC(Cc2ccc(cc2)-c2ccncc2)C1=O
Structure:
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