Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM246806
Substrate
n/a
Meas. Tech.
Receptor Inhibition Assay
pH
7.5±n/a
IC50
5.00±n/a nM
Comments
extracted
Citation
 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Heterocyclic ring and carbocyclic derivative US Patent  US9550763 Publication Date 1/24/2017 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM246806
Synonyms:
US9550763, Compound I-478
Type:
Small organic molecule
Emp. Form.:
C28H25ClN4O5
Mol. Mass.:
532.975
SMILES:
OC(=O)c1cccc(Oc2ccc(cc2)\N=c2/[nH]cc(C3CCOCC3)c(=O)n2Cc2ccc(Cl)cc2)n1
Structure:
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