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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM230088
Substrate
n/a
Meas. Tech.
Tyrosine Kinase Assay
IC50
>2000±n/a nM
Citation
 Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent  US9850258 Publication Date 12/26/2017 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM230088
Synonyms:
US10106559, Example 48 | US10435415, Example 48 | US9334290, 10 | US9850258, Example 48
Type:
Small organic molecule
Emp. Form.:
C31H23ClF2N4O4
Mol. Mass.:
588.989
SMILES:
Cc1c(cccc1-n1c(=O)[nH]c2c(F)cc(F)cc2c1=O)-c1c(Cl)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.47,,;1.14,-.77,;-.2,,;-1.53,-.77,;-1.53,-2.31,;-.2,-3.08,;1.14,-2.31,;2.47,-3.08,;2.47,-4.62,;1.14,-5.39,;3.8,-5.39,;5.14,-4.62,;6.47,-5.39,;6.47,-6.93,;7.8,-4.62,;7.8,-3.08,;9.14,-2.31,;6.47,-2.31,;5.14,-3.08,;3.8,-2.31,;3.8,-.77,;-.2,1.54,;1.14,2.31,;2.47,1.54,;1.14,3.85,;-.2,4.62,;-.2,6.16,;1.14,6.93,;-1.53,6.93,;-1.53,3.85,;-3,4.33,;-3.9,3.08,;-5.43,2.92,;-6.06,1.51,;-5.15,.27,;-3.62,.43,;-3,1.83,;-1.53,2.31,;-7.6,1.51,;-8.37,.18,;-9.14,1.51,;-8.37,2.85,)|
Structure:
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