Reaction Details Report a problem with these data
Target
AP-4-A phosphorylase
Ligand
BDBM65567
Substrate
n/a
Meas. Tech.
FRET assay
pH
8±n/a
IC50
4620±760 nM
Comments
extracted
Citation
 Götz, KH; Hacker, SM; Mayer, D; Dürig, JN; Stenger, S; Marx, A Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis. ACS Chem Biol 12:2682-2689 (2017) [PubMed]  Article 
Target
Name:
AP-4-A phosphorylase
Synonyms:
AP,A phosphorylase | AP4A_MYCTU | ATP adenylyltransferase
Type:
Protein
Mol. Mass.:
21869.52
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WMK9
Residue:
195
Sequence:
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
  
Inhibitor
Name:
BDBM65567
Synonyms:
Synthesized Sulfanylacrylonitril Derivatives 14
Type:
Small organic molecule
Emp. Form.:
C17H16N2O2S2
Mol. Mass.:
344.451
SMILES:
CS\C(Nc1cccc(C)c1)=C(\C#N)S(=O)(=O)c1ccccc1
Structure:
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