Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM174783
Substrate
n/a
Meas. Tech.
P2X7 FLIPR Assay
pH
7.4±n/a
IC50
8.20±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA P2X7 modulators US Patent  US10053462 Publication Date 8/21/2018 
Target
Name:
P2X purinoceptor 7
Synonyms:
P2RX7_MOUSE | P2rx7 | P2x7
Type:
PROTEIN
Mol. Mass.:
68405.16
Organism:
Mus musculus
Description:
ChEMBL_1473824
Residue:
595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
  
Inhibitor
Name:
BDBM174783
Synonyms:
US10053462, 14 | US9102686, 14 | US9540388, 14
Type:
Small organic molecule
Emp. Form.:
C21H17ClF3N5O
Mol. Mass.:
447.841
SMILES:
FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cccnc4)n2C3)c1Cl |r,THB:9:11:17.27.28:13.15.14|
Structure:
Search PDB for entries with ligand similarity: