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Target
P2X purinoceptor 7
Ligand
BDBM174809
Substrate
n/a
Meas. Tech.
P2X7 Radioligand Binding Assay
Ki
35.5±n/a nM
Citation
 Letavic, MA; Rudolph, DA P2X7 modulators US Patent  US10053462 Publication Date 8/21/2018 
Target
Name:
P2X purinoceptor 7
Synonyms:
P2RX7_MOUSE | P2rx7 | P2x7
Type:
PROTEIN
Mol. Mass.:
68405.16
Organism:
Mus musculus
Description:
ChEMBL_1473824
Residue:
595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
  
Inhibitor
Name:
BDBM174809
Synonyms:
US10053462, 40 | US9102686, 40 | US9540388, 40
Type:
Small organic molecule
Emp. Form.:
C21H15ClF4N4O
Mol. Mass.:
450.817
SMILES:
Fc1ccc(cc1)-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F |r,THB:18:17:10.16.15:13.12|
Structure:
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