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Target
P2X purinoceptor 7
Ligand
BDBM174828
Substrate
n/a
Meas. Tech.
P2X7 FLIPR Assay
pH
7.4±n/a
IC50
>10000±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA P2X7 modulators US Patent  US10053462 Publication Date 8/21/2018 
Target
Name:
P2X purinoceptor 7
Synonyms:
P2RX7_MOUSE | P2rx7 | P2x7
Type:
PROTEIN
Mol. Mass.:
68405.16
Organism:
Mus musculus
Description:
ChEMBL_1473824
Residue:
595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
  
Inhibitor
Name:
BDBM174828
Synonyms:
US10053462, 59 | US9102686, 59 | US9540388, 59
Type:
Small organic molecule
Emp. Form.:
C19H15ClF3N5OS
Mol. Mass.:
453.869
SMILES:
Cc1ncsc1-c1nnc2[C@H]3CC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F |r,THB:17:16:9.15.14:12.11|
Structure:
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