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Target
D(1A) dopamine receptor
Ligand
BDBM364311
Substrate
n/a
Meas. Tech.
cAMP HTRF Assay
Ki
179±n/a nM
Citation
 Gray, DL; Davoren, JE; Dounay, AB; Efremov, IV; Mente, SR; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US9856263 Publication Date 1/2/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM364311
Synonyms:
US9856263, 31
Type:
Small organic molecule
Emp. Form.:
C20H17FN4O
Mol. Mass.:
348.3736
SMILES:
Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)c(F)c1C |(4.52,.38,;4.52,1.93,;5.85,2.69,;5.85,4.23,;4.52,5,;3.19,4.23,;1.85,5,;3.19,2.69,;1.85,1.93,;1.85,.38,;.52,-.38,;-.82,.38,;-2.15,-.38,;-2.15,-1.93,;-.82,-2.69,;-.82,-4.23,;-2.15,-5,;-3.48,-4.23,;-4.95,-4.71,;-5.85,-3.47,;-4.95,-2.22,;-3.48,-2.69,;-.82,1.93,;-2.15,2.69,;.52,2.69,;.52,4.23,)|
Structure:
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