Reaction Details Report a problem with these data
Target
Thymidine phosphorylase
Ligand
BDBM20059
Substrate
BDBM1
Meas. Tech.
Enzyme Inhibition Assay
pH
6.4±n/a
Temperature
310.15±n/a K
Ki
1060±200 nM
Km
121000±19000 nM
Citation
Nencka, R; Votruba, I; Hrebabecký, H; Jansa, P; Tloust'ova, E; Horska, K; Masojídkova, M; Holý, A Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase. J Med Chem 50:6016-23 (2007) [PubMed] Article
More Info.:
Target
Name:
Thymidine phosphorylase
Synonyms:
ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Homo sapiens (Human)
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
Inhibitor
Name:
BDBM20059
Synonyms:
5-Substituted-6-chlorouracil, 5f | 6-chloro-5-heptyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Type:
Small organic molecule
Emp. Form.:
C11H17ClN2O2
Mol. Mass.:
244.718
SMILES:
CCCCCCCc1c(Cl)[nH]c(=O)[nH]c1=O