Target
Thymidine phosphorylase
Ligand
BDBM20059
Substrate
BDBM1
Meas. Tech.
Enzyme Inhibition Assay
pH
6.4±n/a
Temperature
310.15±n/a K
Ki
1060±200 nM
Km
121000±19000 nM
Citation
 Nencka, RVotruba, IHrebabecký, HJansa, PTloust'ova, EHorska, KMasojídkova, MHolý, A Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase. J Med Chem 50:6016-23 (2007) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Homo sapiens (Human)
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
  
Inhibitor
Name:
BDBM20059
Synonyms:
5-Substituted-6-chlorouracil, 5f | 6-chloro-5-heptyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Type:
Small organic molecule
Emp. Form.:
C11H17ClN2O2
Mol. Mass.:
244.718
SMILES:
CCCCCCCc1c(Cl)[nH]c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM1
Synonyms:
dT | thymidine
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H14N2O5
Mol. Mass.:
242.2286
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: