Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM20109
Substrate
BDBM20081
Meas. Tech.
Papain Inhibition Assay
pH
6.5±n/a
Temperature
298.15±n/a K
Ki
460±20 nM
Km
965000±244000 nM
Citation
 Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed]  Article 
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM20109
Synonyms:
dipeptide-derived nitrile, 30 | tert-butyl N-[(1S)-2-(2-bromophenyl)-1-[(cyanomethyl)carbamoyl]ethyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C16H20BrN3O3
Mol. Mass.:
382.252
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1Br)C(=O)NCC#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM20081
Synonyms:
Z-Phe-Arg-NH-4-nitrophenyl | Z-Phe-Arg-NHNp
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: