Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM20101
Substrate
BDBM20130
Meas. Tech.
Papain Inhibition Assay
Ki
>100000±n/a nM
Citation
Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed] Article
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM20101
Synonyms:
dipeptide-derived nitrile, 22 | tert-butyl N-[(1S)-2-(benzyloxy)-1-[(cyanomethyl)carbamoyl]ethyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C17H23N3O4
Mol. Mass.:
333.3822
SMILES:
CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)NCC#N |r|