Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM364423
Substrate
n/a
Meas. Tech.
Uptake Assays
Ki
176±26.3 nM
Citation
 Newman, AH; Okunola-Bakare, OM; Cao, J Potent and selective inhibitors of monoamine transporters; method of making; and use thereof US Patent  US9862679 Publication Date 1/9/2018 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM364423
Synonyms:
US10913711, Compound 10j | US11555013, Compound 10j | US9862679, Compound 10j
Type:
Small organic molecule
Emp. Form.:
C28H32F2N2O2S
Mol. Mass.:
498.628
SMILES:
OC(CN1CCN(CCS(=O)C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: