Target
Tyrosine-protein kinase JAK2
Ligand
BDBM364373
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
8336±n/a nM
Citation
 Gray, NSTan, L Hydrophobically tagged janus kinase inhibitors and uses thereof US Patent  US9862688 Publication Date 1/9/2018 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM364373
Synonyms:
US9862688, Compound 1
Type:
Small organic molecule
Emp. Form.:
C39H49ClN8O3
Mol. Mass.:
713.311
SMILES:
COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(CCNC(=O)CC2[C@H]3CC4C[C@@H](C[C@@H]2C4)C3)CC1 |r,wU:46.50,40.43,44.46,THB:41:42:45:39.40.48,43:42:39:44.45.48,(-2,-2.7,;-2,-1.16,;-.67,-.39,;.67,-1.16,;2,-.39,;2,1.15,;.67,1.92,;-.67,1.15,;-2,1.92,;-3.33,1.15,;-3.33,-.39,;-4.67,-1.16,;-6,-.39,;-7.34,-1.15,;-6,1.15,;-7.34,1.92,;-8.67,1.15,;-10,1.92,;-10,3.46,;-11.34,4.23,;-12.67,3.46,;-12.67,1.92,;-14,1.15,;-15.34,1.92,;-15.34,3.46,;-16.67,1.15,;-18,1.92,;-11.34,1.15,;-4.67,1.93,;3.33,-1.16,;3.33,-2.7,;4.67,-3.47,;6,-2.7,;7.34,-3.47,;8.67,-2.7,;10,-3.47,;11.34,-2.7,;11.34,-1.16,;12.67,-3.47,;14,-2.7,;14,-1.16,;15.34,-.39,;16.67,-1.16,;18,-1.93,;18,-3.47,;16.67,-4.23,;15.34,-3.46,;16.67,-2.7,;16.23,-1.83,;6,-1.16,;4.67,-.39,)|
Structure:
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