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Target
Non-receptor tyrosine-protein kinase TYK2
Ligand
BDBM364420
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
1.64±n/a nM
Citation
 Gray, NS; Tan, L Hydrophobically tagged janus kinase inhibitors and uses thereof US Patent  US9862688 Publication Date 1/9/2018 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2
Type:
Protein
Mol. Mass.:
133666.03
Organism:
Homo sapiens (Human)
Description:
P29597
Residue:
1187
Sequence:
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM364420
Synonyms:
US9862688, Compound 6
Type:
Small organic molecule
Emp. Form.:
C34H41ClN8O2
Mol. Mass.:
629.195
SMILES:
Clc1cnc(Nc2cnn(c2)C2CCN(CC2)C(=O)CC2[C@H]3CC4C[C@@H](C[C@H]2C4)C3)nc1NCc1cccc(NC(=O)C=C)c1 |r,wD:27.30,21.23,25.26,THB:22:23:20.21.29:26,24:23:20:29.25.26,(4.11,-3.59,;3.34,-2.25,;1.8,-2.25,;1.03,-.92,;1.8,.41,;1.03,1.75,;-.51,1.75,;-1.42,2.99,;-2.88,2.52,;-2.88,.98,;-1.42,.5,;-4.22,.21,;-4.22,-1.33,;-5.55,-2.1,;-6.88,-1.33,;-6.88,.21,;-5.55,.98,;-8.22,-2.1,;-8.22,-3.64,;-9.55,-1.33,;-10.89,-2.1,;-12.22,-1.33,;-13.55,-2.1,;-13.55,-3.64,;-14.89,-2.87,;-14.89,-1.33,;-12.61,-3.15,;-10.89,-3.64,;-12.22,-4.41,;-13.55,-.56,;3.34,.41,;4.11,-.92,;5.65,-.92,;6.42,.41,;7.96,.41,;8.73,-.92,;10.27,-.92,;11.04,.41,;10.27,1.75,;11.04,3.08,;12.58,3.08,;13.35,1.75,;13.35,4.41,;14.89,4.41,;8.73,1.75,)|
Structure:
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