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Target
Tyrosine-protein kinase JAK3
Ligand
BDBM364422
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
105±n/a nM
Citation
 Gray, NS; Tan, L Hydrophobically tagged janus kinase inhibitors and uses thereof US Patent  US9862688 Publication Date 1/9/2018 
Target
Name:
Tyrosine-protein kinase JAK3
Synonyms:
JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase
Type:
Protein
Mol. Mass.:
125111.08
Organism:
Homo sapiens (Human)
Description:
P52333
Residue:
1124
Sequence:
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM364422
Synonyms:
US9862688, Compound 7
Type:
Small organic molecule
Emp. Form.:
C36H46ClN9O2
Mol. Mass.:
672.263
SMILES:
Clc1cnc(Nc2cnn(c2)C2CCN(CCNC(=O)CC3[C@H]4C[C@@H]5C[C@H](C[C@@H]3C5)C4)CC2)nc1NCc1cccc(NC(=O)C=C)c1 |r,wU:22.33,26.32,28.28,24.25,THB:23:24:27:22.30.21,21:28:25:22.30.23,(-6.11,4,;-5.34,2.67,;-3.8,2.67,;-3.03,1.33,;-3.8,,;-3.03,-1.33,;-1.49,-1.33,;-.58,-2.58,;.88,-2.1,;.88,-.56,;-.58,-.09,;2.22,.21,;3.55,-.56,;4.88,.21,;4.88,1.75,;6.22,2.52,;7.55,1.75,;8.88,2.52,;10.22,1.75,;10.22,.21,;11.55,2.52,;12.89,1.75,;12.89,.21,;14.61,.7,;16.89,2.52,;16.89,.98,;15.55,.21,;15.55,1.75,;14.22,2.52,;15.55,3.29,;14.22,-.56,;3.55,2.52,;2.22,1.75,;-5.34,,;-6.11,1.33,;-7.65,1.33,;-8.42,,;-9.96,,;-10.73,1.33,;-12.27,1.33,;-13.04,,;-12.27,-1.33,;-13.04,-2.67,;-14.58,-2.67,;-15.35,-1.33,;-15.35,-4,;-16.89,-4,;-10.73,-1.33,)|
Structure:
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