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Target
Signal transducer and activator of transcription 3
Ligand
BDBM20249
Substrate
c-fos sis inducible element (hSIE)
Meas. Tech.
Electrophoretic Mobility Shift Assay (EMSA)
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
6000±n/a nM
Citation
 Ren, Z; Cabell, LA; Schaefer, TS; McMurray, JS Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg Med Chem Lett 13:633-6 (2003) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3
Type:
Cytosolic Transcription Factor
Mol. Mass.:
88050.28
Organism:
Mus musculus (mouse)
Description:
Bacterially expressed protein was used in the FP assay.
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
  
Inhibitor
Name:
BDBM20249
Synonyms:
4-[(2S)-2-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl}propyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}butyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid | Y(p)RHQVP | gp130 (767) derived peptide, 4
Type:
Phosphopeptide
Emp. Form.:
C38H58N13O12P
Mol. Mass.:
919.9208
SMILES:
CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(N)=O |r,wU:26.34,7.12,wD:37.51,16.23,3.3,60.63,(11.96,1.76,;10.62,2.53,;9.29,1.76,;10.62,4.07,;9.29,4.84,;7.95,4.07,;7.95,2.53,;6.62,4.84,;6.62,6.38,;7.95,7.15,;7.95,8.69,;6.62,9.46,;9.29,9.46,;5.29,4.07,;3.95,4.84,;3.95,6.38,;2.62,4.07,;2.62,2.53,;3.39,1.2,;2.93,-.27,;4.19,-1.16,;5.42,-.24,;4.93,1.22,;1.29,4.84,;-.05,4.07,;-.05,2.53,;-1.38,4.84,;-1.38,6.38,;-.05,7.15,;-.05,8.69,;1.29,9.46,;1.29,11,;2.62,11.77,;-.05,11.77,;-2.72,4.07,;-4.05,4.84,;-4.05,6.38,;-5.38,4.07,;-5.38,2.53,;-6.72,1.76,;-8.05,2.53,;-9.38,1.76,;-9.38,.22,;-10.72,-.55,;-10.72,-2.09,;-10.72,-3.63,;-9.18,-2.09,;-12.26,-2.09,;-8.05,-.55,;-6.72,.22,;-6.72,4.84,;-6.72,6.38,;-8.05,7.15,;-5.38,7.15,;11.96,4.84,;11.96,6.38,;13.29,4.07,;13.65,2.58,;15.19,2.46,;15.77,3.89,;14.6,4.88,;14.71,6.42,;13.44,7.28,;16.1,7.09,)|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
c-fos sis inducible element (hSIE)
Synonyms:
32P-labeled c-fos sis inducible element (hSIE)
Type:
Oligonucleotide
Mol. Mass.:
2192.56
Organism:
n/a
Description:
hSIE derived from the c-fos gene promoter.
Residue:
24
Sequence:
AGCTTCATTTCCCGTAAATCCCTA