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Target
P2X purinoceptor 7
Ligand
BDBM160080
Substrate
n/a
Meas. Tech.
P2X7 Radioligand Binding
Ki
3.50±n/a nM
Citation
 Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent  US10053463 Publication Date 8/21/2018 
Target
Name:
P2X purinoceptor 7
Synonyms:
P2RX7_MOUSE | P2rx7 | P2x7
Type:
PROTEIN
Mol. Mass.:
68405.16
Organism:
Mus musculus
Description:
ChEMBL_1473824
Residue:
595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
  
Inhibitor
Name:
BDBM160080
Synonyms:
US10047092, 21 | US10053463, 21 | US9040534, 21
Type:
Small organic molecule
Emp. Form.:
C17H13ClF3N5O2
Mol. Mass.:
411.766
SMILES:
C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cocn1 |r|
Structure:
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