Reaction Details Report a problem with these data
Target
Ribosomal protein S6 kinase beta-1 [T412E]
Ligand
BDBM365003
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
5.5±n/a nM
Citation
 Lan, R; Chen, X; Xiao, Y; Huck, BR; Goutopoulos, A Heterocycles as modulators of kinase activity US Patent  US9867826 Publication Date 1/16/2018 
Target
Name:
Ribosomal protein S6 kinase beta-1 [T412E]
Synonyms:
KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59166.89
Organism:
Homo sapiens (Human)
Description:
P23443[T412E]
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM365003
Synonyms:
4-Amino-6-{cis-4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-pyrimidine-5-carboxylic acid amide | US9867826, Compound 19 | US9867826, Compound 27
Type:
Small organic molecule
Emp. Form.:
C25H30F2N8O
Mol. Mass.:
496.5555
SMILES:
Cc1cc(ccc1F)-c1cn(CCN2CCC2)c(n1)[C@@H]1CCN(C[C@@H]1F)c1ncnc(N)c1C(N)=O
Structure:
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