Target
Ribosomal protein S6 kinase beta-1 [T412E]
Ligand
BDBM365012
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
5.5±n/a nM
Citation
 Lan, RChen, XXiao, YHuck, BRGoutopoulos, A Heterocycles as modulators of kinase activity US Patent  US9867826 Publication Date 1/16/2018 
Target
Name:
Ribosomal protein S6 kinase beta-1 [T412E]
Synonyms:
KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59166.89
Organism:
Homo sapiens (Human)
Description:
P23443[T412E]
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM365012
Synonyms:
6-{cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-5-isopropyl-pyrimidin-4-ylamine | US9867826, Compound 24 | US9867826, Compound 35
Type:
Small organic molecule
Emp. Form.:
C27H35F2N7
Mol. Mass.:
495.6105
SMILES:
CC(C)c1c(N)ncnc1N1CC[C@H]([C@@H](F)C1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(C)c1
Structure:
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