Target
D(1A) dopamine receptor
Ligand
BDBM285640
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
44.7±n/a nM
Citation
 Gray, DLZhang, LDavoren, JEDounay, ABEfremov, IVLee, CMente, SRO Neil, SVRogers, BNSubramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US9868744 Publication Date 1/16/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285640
Synonyms:
5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl]-4,6-dimethylpyridazin-3(2H)-one | US10077272, Example 6 | US9868744, 8
Type:
Small organic molecule
Emp. Form.:
C19H16N4O3
Mol. Mass.:
348.3553
SMILES:
Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C |(-3.81,-14.36,;-3.81,-15.9,;-5.14,-16.67,;-5.14,-18.21,;-6.48,-18.98,;-6.48,-20.52,;-5.14,-21.29,;-5.14,-22.83,;-6.48,-23.6,;-7.81,-22.83,;-9.27,-23.31,;-10.18,-22.06,;-9.27,-20.82,;-7.81,-21.29,;-3.81,-18.98,;-2.47,-18.21,;-2.47,-16.67,;-1.14,-15.9,;.19,-16.67,;.19,-18.21,;1.53,-15.9,;1.53,-14.36,;.19,-13.59,;.19,-12.05,;-1.14,-14.36,;-2.47,-13.59,)|
Structure:
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