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Target
3-phosphoinositide-dependent protein kinase 1 [51-360]
Ligand
BDBM366285
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<500±n/a nM
Citation
 Lind, KE; Cao, K; Lin, EY; Nguyen, TB; Tangonan, BT; Erlanson, DA; Guckian, K; Simmons, RL; Lee, W; Sun, L; Hansen, S; Pathan, N; Zhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent  US9873693 Publication Date 1/23/2018 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-360]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35373.34
Organism:
Homo sapiens (Human)
Description:
(aa 51-360)
Residue:
310
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
  
Inhibitor
Name:
BDBM366285
Synonyms:
US9873693, Compound 208
Type:
Small organic molecule
Emp. Form.:
C27H19F4N5O2
Mol. Mass.:
521.4657
SMILES:
FC(F)c1cc(cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1)-c1c[nH]c2ncccc12
Structure:
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