Reaction Details Report a problem with these data
Target
3-phosphoinositide-dependent protein kinase 1 [51-360]
Ligand
BDBM366335
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<500±n/a nM
Citation
 Lind, KE; Cao, K; Lin, EY; Nguyen, TB; Tangonan, BT; Erlanson, DA; Guckian, K; Simmons, RL; Lee, W; Sun, L; Hansen, S; Pathan, N; Zhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent  US9873693 Publication Date 1/23/2018 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-360]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35373.34
Organism:
Homo sapiens (Human)
Description:
(aa 51-360)
Residue:
310
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
  
Inhibitor
Name:
BDBM366335
Synonyms:
US9873693, Compound 262
Type:
Small organic molecule
Emp. Form.:
C23H22ClN5O3
Mol. Mass.:
451.905
SMILES:
COc1ccnc(NCCC#CCNC(=O)c2cccn(Cc3cccc(Cl)c3)c2=O)n1
Structure:
Search PDB for entries with ligand similarity: