Reaction Details Report a problem with these data
Target
Heat shock protein HSP 90-beta
Ligand
BDBM20783
Substrate
BDBM10852
Meas. Tech.
Her-2 Degradation Assay
EC50
28±n/a nM
Citation
 Zhang, L; Fan, J; Vu, K; Hong, K; Le Brazidec, JY; Shi, J; Biamonte, M; Busch, DJ; Lough, RE; Grecko, R; Ran, Y; Sensintaffar, JL; Kamal, A; Lundgren, K; Burrows, FJ; Mansfield, R; Timony, GA; Ulm, EH; Kasibhatla, SR; Boehm, MF 7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors. J Med Chem 49:5352-62 (2006) [PubMed]  Article 
Target
Name:
Heat shock protein HSP 90-beta
Synonyms:
HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90)
Type:
Molecular Chaperone
Mol. Mass.:
83229.45
Organism:
Homo sapiens (Human)
Description:
P08238
Residue:
724
Sequence:
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
  
Inhibitor
Name:
BDBM20783
Synonyms:
CHEMBL212133 | Pyridothiazole analogue, 27 | diethyl {2-[6-amino-8-({7-bromopyrido[3,4-d][1,3]thiazol-2-yl}sulfanyl)-9H-purin-9-yl]ethyl}phosphonate
Type:
Small organic molecule
Emp. Form.:
C17H19BrN7O3PS2
Mol. Mass.:
544.386
SMILES:
CCOP(=O)(CCn1c(Sc2nc3cncc(Br)c3s2)nc2c(N)ncnc12)OCC
Structure:
Search PDB for entries with ligand similarity:
Substrate