Reaction Details
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Hemagglutinin
Ligand
BDBM247015
Substrate
n/a
Meas. Tech.
Endonuclease Assay
pH
7.5±n/a
IC50
10600±n/a nM
Comments
extracted
Citation
Lavoie, EJ; Bauman, JD; Sagong, HY; Arnold, E; Parhi, A; Das, K; Vijayan, SK; Patel, D Therapeutic hydroxyquinolones US Patent US9701638 Publication Date 7/11/2017 More Info.:
Target
Name:
Hemagglutinin
Synonyms:
HA | Hemagglutinin HA1 chain
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63281.44
Organism:
Influenza A virus (strain swl A/California/04/2009 H1N1)
Description:
C3W5S1
Residue:
566
Sequence:
MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADTYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAISFWMCSNGSLQCRICI
Inhibitor
Name:
BDBM247015
Synonyms:
US9701638, 6
Type:
Small organic molecule
Emp. Form.:
C9H6BrNO2
Mol. Mass.:
240.053
SMILES:
Oc1cc2cccc(Br)c2[nH]c1=O
Structure:
