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Reaction Details
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TargetCathepsin L1
LigandBDBM20995
Substrate/CompetitorBDBM20994
Meas. Tech.Enzyme Inhibition Assay
pH5.5±n/a
Temperature298.15±n/a K
Ki 155±n/a nM
Citation Chowdhury, SFJoseph, LKumar, STulsidas, SRBhat, SZiomek, EMénard, RSivaraman, JPurisima, EO Exploring inhibitor binding at the s' subsites of cathepsin L. J Med Chem51:1361-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
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BDBM20995
NameBDBM20995
Synonyms:(2R)-2-[(2R)-3-(benzylsulfanyl)-2-[1-(4-phenylphenyl)acetamido]propanamido]-5-[(diaminomethylidene)amino]-N-[(1S)-2-(4-hydroxyphenyl)-1-[(2-phenylethyl)carbamoyl]ethyl]pentanamide | Tripeptide derivative, 2
TypeSmall organic molecule
Emp. Form.C47H53N7O5S
Mol. Mass.828.033
SMILES[#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#16]-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-c1ccc(cc1)-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6]-c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM20994
NameBDBM20994
Synonyms:Cbz-Phe-Arg-MCA | Fluorogenic substrate | benzyloxycarbonyl-L-phenylalanyl-L-arginine 4-methylcoumarinyl-7-amide hydrochloride
Typen/a
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure