Reaction Details |
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Target | Cathepsin L1 |
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Ligand | BDBM20995 |
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Substrate/Competitor | BDBM20994 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 5.5±n/a |
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Temperature | 298.15±n/a K |
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Ki | 155±n/a nM |
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Citation | Chowdhury, SF; Joseph, L; Kumar, S; Tulsidas, SR; Bhat, S; Ziomek, E; Ménard, R; Sivaraman, J; Purisima, EO Exploring inhibitor binding at the s' subsites of cathepsin L. J Med Chem51:1361-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin L1 |
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Name: | Cathepsin (L and K) |
Synonyms: | Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM20995 |
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Name | BDBM20995 |
Synonyms: | (2R)-2-[(2R)-3-(benzylsulfanyl)-2-[1-(4-phenylphenyl)acetamido]propanamido]-5-[(diaminomethylidene)amino]-N-[(1S)-2-(4-hydroxyphenyl)-1-[(2-phenylethyl)carbamoyl]ethyl]pentanamide | Tripeptide derivative, 2 |
Type | Small organic molecule |
Emp. Form. | C47H53N7O5S |
Mol. Mass. | 828.033 |
SMILES | [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#16]-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-c1ccc(cc1)-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6]-c1ccccc1 |r| |
Structure |
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BDBM20994 |
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Name | BDBM20994 |
Synonyms: | Cbz-Phe-Arg-MCA | Fluorogenic substrate | benzyloxycarbonyl-L-phenylalanyl-L-arginine 4-methylcoumarinyl-7-amide hydrochloride |
Type | n/a |
Emp. Form. | n/a |
Mol. Mass. | n/a |
SMILES | n/a |
Structure |
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