Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM21003
Substrate
BDBM20994
Meas. Tech.
Enzyme Inhibition Assay
pH
5.5±n/a
Temperature
298.15±n/a K
Ki
10700±n/a nM
Citation
 Chowdhury, SF; Joseph, L; Kumar, S; Tulsidas, SR; Bhat, S; Ziomek, E; Ménard, R; Sivaraman, J; Purisima, EO Exploring inhibitor binding at the s' subsites of cathepsin L. J Med Chem 51:1361-8 (2008) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM21003
Synonyms:
(2R)-5-[(diaminomethylidene)amino]-2-[(2S)-2-formamido-2-[1-(4-phenylphenyl)acetamido]ethan-1-aminium]-N-[(1S)-2-(4-hydroxyphenyl)-1-[(2-phenylethyl)carbamoyl]ethyl]pentanamide | Tripeptide derivative, 11
Type:
Small organic molecule
Emp. Form.:
C40H49N8O5
Mol. Mass.:
721.8671
SMILES:
[#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#7+])-[#7]-[#6](=O)-[#6]-c1ccc(cc1)-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6]-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM20994
Synonyms:
Cbz-Phe-Arg-MCA | Fluorogenic substrate | benzyloxycarbonyl-L-phenylalanyl-L-arginine 4-methylcoumarinyl-7-amide hydrochloride
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: