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Target
Ceramide glucosyltransferase
Ligand
BDBM367660
Substrate
n/a
Meas. Tech.
GCS Enzymatic Assay
IC50
5.5±n/a nM
Citation
 Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent  US10227312 Publication Date 3/12/2019 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM367660
Synonyms:
N-((1R,2R)-1-(4-cyclopropoxy-3- fluorophenyl)-1-hydroxy-3-(pyrrolidin- 1-yl)propan-2-yl)-1-methyl-1,9- dihydro[1,2]oxazino[4,5-g]indazole-6- carboxamide | US10227312, Example 46 | US10759769, Example 46
Type:
Small organic molecule
Emp. Form.:
C27H30FN5O4
Mol. Mass.:
507.5566
SMILES:
Cn1ncc2ccc3C(=NOCc3c12)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(F)c1 |r,c:8|
Structure:
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