Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM367667
Substrate
n/a
Meas. Tech.
CSE In Vitro Assay
IC50
>100000±n/a nM
Citation
 Durón, SG; Chapman, J; Sydserff, SG; Rao, SG; Stein, G Cystathionine-gamma-lyase (CSE) inhibitors US Patent  US10227314 Publication Date 3/12/2019 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM367667
Synonyms:
(S)-5-(1-aminobut-3-ynyl)-1H-1,2,4-triazol-3-amine hydrochloride | US10227314, Example 6
Type:
Small organic molecule
Emp. Form.:
C6H9N5
Mol. Mass.:
151.1692
SMILES:
N[C@@H](CC#C)c1nc(N)n[nH]1 |r|
Structure:
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