Reaction Details Report a problem with these data
Target
VIM-2 type metallo-beta-lactamase
Ligand
BDBM367685
Substrate
n/a
Meas. Tech.
MBL Inhibitory Activity in Constructed E. coli Cells Expressing MBLs
IC50
12860±n/a nM
Citation
 Rongved, P; Åstrand, OA; Bayer, A; Leiros, HS; Samuelsen, null; Edvardsen, KS; Muhammad, Z Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety US Patent  US10227327 Publication Date 3/12/2019 
Target
Name:
VIM-2 type metallo-beta-lactamase
Synonyms:
VIM-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM367685
Synonyms:
1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)methanamine (OAA4085) | US10227327, Example 12
Type:
Small organic molecule
Emp. Form.:
C22H19F3N6
Mol. Mass.:
424.4217
SMILES:
FC(F)(F)c1ccc(cc1)-n1cc(CN(Cc2ccccn2)Cc2ccccn2)nn1
Structure:
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