Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM368207
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
39.0±n/a nM
Citation
 Liverton, N; Kuduk, SD; Luo, Y Pyrazole orexin receptor antagonists US Patent  US10227336 Publication Date 3/12/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM368207
Synonyms:
(2R,5S)-5-(1-cyclopentyl-1H- pyrazol-4-yl)-2-methyl-1-{[2-(2H- 1,2,3-triazol-2- yl)phenyl]carbonyl}piperidine | US10227336, Example 4
Type:
Small organic molecule
Emp. Form.:
C23H28N6O
Mol. Mass.:
404.508
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1cnn(c1)C1CCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: