Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM368217
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
430±n/a nM
Citation
 Liverton, N; Kuduk, SD; Luo, Y Pyrazole orexin receptor antagonists US Patent  US10227336 Publication Date 3/12/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM368217
Synonyms:
(2R,5S)-2-methyl-5-[1-(1- methylethyl)-1H-pyrazol-4-yl]-1- {[4-(2H-1,2,3-triazol-2-yl)thiophen- 3-yl]carbonyl}piperidine | US10227336, Example 14
Type:
Small organic molecule
Emp. Form.:
C19H24N6OS
Mol. Mass.:
384.498
SMILES:
CC(C)n1cc(cn1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1 |r|
Structure:
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