Reaction Details Report a problem with these data
Target
Cytochrome P450 2C9
Ligand
BDBM21152
Substrate
BDBM21171
Meas. Tech.
CYP3A4 Enzyme Inhibition Assay
IC50
>30000±n/a nM
Citation
 Ahlström, MM; Zamora, I Characterization of Type II Ligands in CYP2C9 and CYP3A4. J Med Chem 51:1755-1763 (2008) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C9
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
55636.33
Organism:
Homo sapiens (Human)
Description:
P11712
Residue:
490
Sequence:
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM21152
Synonyms:
N-(4-ethoxyphenyl)-4-(1H-1,2,3,4-tetrazol-1-yl)benzamide | Tetrazole-based ligand, 3
Type:
Small organic molecule
Emp. Form.:
C16H15N5O2
Mol. Mass.:
309.3226
SMILES:
CCOc1ccc(NC(=O)c2ccc(cc2)-n2cnnn2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21171
Synonyms:
7-methoxy-4-(trifluoromethyl)-2H-chromen-2-one | 7-methoxy-4-trifluoromethylcoumarin | MFC
Type:
Small organic molecule
Emp. Form.:
C11H7F3O3
Mol. Mass.:
244.1667
SMILES:
COc1ccc2c(cc(=O)oc2c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: