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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM203306
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
IC50
616±n/a nM
Citation
 Paidi, VR; Kumar, SR; Banerjee, A; Sistla, RK; Nair, SK; Pitts, WJ; Hynes, J Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors US Patent  US10227340 Publication Date 3/12/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM203306
Synonyms:
US10227340, Example 176 | US9242975, 176
Type:
Small organic molecule
Emp. Form.:
C21H21N5OS
Mol. Mass.:
391.489
SMILES:
COc1cccc(n1)-c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C
Structure:
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