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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368594
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
150±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368594
Synonyms:
US10227350, Compound 15
Type:
Small organic molecule
Emp. Form.:
C24H18ClN5O
Mol. Mass.:
427.886
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)-c1ccnc(C)c1)C(N)=O |(-4.86,-.54,;-3.37,-.94,;-2.89,-2.4,;-1.35,-2.4,;-.32,-3.55,;1.18,-3.23,;1.66,-1.76,;.63,-.62,;-.88,-.94,;-2.12,-.03,;-2.12,1.51,;-.79,2.28,;-.79,3.82,;-2.12,4.59,;-3.46,3.82,;-4.79,4.59,;-4.79,6.13,;-6.12,3.82,;-6.12,2.28,;-4.79,1.51,;-3.46,2.28,;3.15,-1.37,;4.24,-2.45,;5.72,-2.06,;6.12,-.57,;5.03,.52,;5.43,2.01,;3.55,.12,;-.72,-5.04,;.37,-6.13,;-2.21,-5.43,)|
Structure:
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