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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368636
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
19.0±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368636
Synonyms:
US10227350, Compound 55
Type:
Small organic molecule
Emp. Form.:
C24H17FN8
Mol. Mass.:
436.4438
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2cccc(F)c12)-c1ccnc(N)c1)-c1nnc[nH]1 |(-5.2,.93,;-3.71,.53,;-3.24,-.93,;-1.7,-.93,;-.67,-2.08,;.84,-1.76,;1.32,-.29,;.28,.85,;-1.22,.53,;-2.47,1.44,;-2.47,2.98,;-1.13,3.75,;-1.13,5.29,;-2.47,6.06,;-3.8,5.29,;-5.13,6.06,;-6.47,5.29,;-6.47,3.75,;-5.13,2.98,;-5.13,1.62,;-3.8,3.75,;2.8,.11,;3.2,1.59,;4.69,1.99,;5.78,.9,;5.38,-.58,;6.47,-1.67,;3.89,-.98,;-1.07,-3.56,;-.16,-4.81,;-1.07,-6.06,;-2.53,-5.58,;-2.53,-4.04,)|
Structure:
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