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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368700
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
3.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368700
Synonyms:
US10227350, Compound 115 | US10227350, Compound 116 | US10227350, Compound 143
Type:
Small organic molecule
Emp. Form.:
C25H14F2N8
Mol. Mass.:
464.4291
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2cc(F)cc(F)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1 |(-5.13,.53,;-3.59,.53,;-3.11,-.93,;-1.57,-.93,;-.54,-2.08,;.96,-1.76,;1.44,-.29,;.41,.85,;-1.1,.53,;-2.34,1.44,;-2.34,2.98,;-1.01,3.75,;-1.01,5.29,;-2.34,6.06,;-3.68,5.29,;-5.01,6.06,;-6.35,5.29,;-7.68,6.06,;-6.35,3.75,;-5.01,2.98,;-5.01,1.44,;-3.68,3.75,;2.93,.11,;3.32,1.59,;4.81,1.99,;5.9,.9,;5.5,-.58,;4.01,-.98,;6.59,-1.67,;7.68,-2.76,;-.94,-3.56,;-.04,-4.81,;-.94,-6.06,;-2.41,-5.58,;-2.41,-4.04,)|
Structure:
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