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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368710
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
780±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368710
Synonyms:
US10227350, Compound 125 | US10227350, Compound 126 | US10227350, Compound 146
Type:
Small organic molecule
Emp. Form.:
C25H15ClN8
Mol. Mass.:
462.893
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2cccc(Cl)c12)-c1ccnc(c1)C#N)-c1nnc[nH]1 |(-5.8,.53,;-4.26,.53,;-3.78,-.93,;-2.24,-.93,;-1.21,-2.08,;.3,-1.76,;.77,-.29,;-.26,.85,;-1.77,.53,;-3.01,1.44,;-3.01,2.98,;-1.68,3.75,;-1.68,5.29,;-3.01,6.06,;-4.35,5.29,;-5.68,6.06,;-7.01,5.29,;-7.01,3.75,;-5.68,2.98,;-5.68,1.44,;-4.35,3.75,;2.26,.11,;2.66,1.59,;4.14,1.99,;5.23,.9,;4.83,-.58,;3.35,-.98,;5.92,-1.67,;7.01,-2.76,;-1.61,-3.56,;-.7,-4.81,;-1.61,-6.06,;-3.07,-5.58,;-3.07,-4.04,)|
Structure:
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